View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Neurology. Wright, G. A., Grandjean, P. W., and Pascoe, D. D. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. J.Strength.Cond.Res. Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds. This can help improve movement and reduce seizures. © 2005 - 2019 WebMD LLC. Effects of creatine supplementation on repetitive sprint performance and body composition in competitive swimmers. Information from this source is evidence-based and objective, and without commercial influence. Med Sci Sports Exerc. Do you have pounds of belly fat you want to lose? Kinugasa, R., Akima, H., Ota, A., Ohta, A., Sugiura, K., and Kuno, S. Y. Med Sci.Sports Exerc. Taking creatine by mouth daily for up to 3 years can increase creatine levels in the brain in children and young adults with a disorder of creatine production called guanidinoacetate methyltransferase (GAMT) deficiency. BMJ 1994;308:501-3. View abstract. Reuters Health 2000;Jun 13. Pastula, D. M., Moore, D. H., and Bedlack, R. S. Creatine for amyotrophic lateral sclerosis/motor neuron disease. An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). Pluim, B. M., Ferrauti, A., Broekhof, F., Deutekom, M., Gotzmann, A., Kuipers, H., and Weber, K. The effects of creatine supplementation on selected factors of tennis specific training. 2003;50(1):190-195. Graham AS, Hatton RC. Osteoarthritis. Oral creatine supplementation (CR) in COPD exercise training: a randomized, double-blind, placebo (PL) controlled trial [Abstract]. View abstract. The effects of creatine supplementation on explosive performance and optimal individual postactivation potentiation time. Delecluse, C., Diels, R., and Goris, M. Effect of creatine supplementation on intermittent sprint running performance in highly trained athletes. Early research shows that taking creatine by mouth daily increases lean muscle mass and may improve muscle strength, but does not improve physical functioning in adults with rheumatoid arthritis. J Spinal Cord.Med 2005;28(3):208-213. Saremi A, Gharakhanloo R Sharghi S Gharaati MR Larijani B Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 2016;5(2):126-34. Febbraio MA, Flanagan TR, Snow RJ, et al. View abstract. Cochrane.Database.Syst.Rev. View abstract. B., de Coo, I. F., Huijmans, J. G., Jakobs, C., van der Knaap, M. S., Salomons, G. S., and Mancini, G. M. Long-term follow-up and treatment in nine boys with X-linked creatine transporter defect. Kley, R. A., Tarnopolsky, M. A., and Vorgerd, M. Creatine treatment in muscle disorders: a meta-analysis of randomised controlled trials. Hultman E, Soderlund K, Timmons JA, et al. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. A., and Schambelan, M. Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study. Most of the health risks attributed to creatine (kidney and liver damage, increased risk of injury) have not been shown in clinical studies. Devries MC, Phillips SM. View abstract. Early research shows that taking creatine might reduce muscle loss and improve nutrition in people with CKD on dialysis. Acute creatine supplementation in older men. Pittas, G., Hazell, M. D., Simpson, E. J., and Greenhaff, P. L. Optimization of insulin-mediated creatine retention during creatine feeding in humans. View abstract. As a result, ATP becomes ADP (adenosine diphosphate). 2009;23(3):906-914. 2016 Jun;30(6):1763-6. (The NCAA won’t let colleges give it to athletes, though. Drory, V. E. and Gross, D. No effect of creatine on respiratory distress in amyotrophic lateral sclerosis. J Strength Cond Res. Int J Sport Nutr.Exerc.Metab 2001;11(3):349-364. View abstract. Ferraro S, Codella C, Palumbo F, et al. View abstract. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). Gotshalk, L. A., Volek, J. S., Staron, R. S., Denegar, C. R., Hagerman, F. C., and Kraemer, W. J. Creatine supplementation improves muscular performance in older men. View abstract. Int J Sport Nutr.Exerc.Metab 2003;13(1):97-111. Clin Sci (Lond) 2004;106(1):99-106. It seems to work best when used along with exercise to build muscles. Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis. View abstract. J Appl Physiol 1996;80:452-7. 2016 Mar 31;13:12. Clin.Neuropharmacol. Pepping J. Creatine. Creapure (Creatine Monohydrate). View abstract. Bosco C, Tihanyi J, Pucspk J, et al. View abstract. Muscle cramping 2. View abstract. Clin Chim.Acta 1-5-2000;290(2):179-188. 2012;4:CD004426. View abstract. View abstract. Ann Pharmacother 2013;47(7-8):e33. Stop using creatine and call your healthcare provider at once if you have: pounding heartbeats or fluttering in your chest; trouble breathing; “[There is] no evidence that this would do anything more in terms of loading the muscle, so why on earth would someone waste money and time and effort for unknown risks and zippo added benefit. Poortmans, J. R. and Francaux, M. Renal dysfunction accompanying oral creatine supplements. J Clin Pharmacol 2003;43:29-37. . View abstract. Med Sci Sports Exerc 2003;35:769-76. Wilder, N., Gilders, R., Hagerman, F., and Deivert, R. G. The effects of a 10-week, periodized, off-season resistance-training program and creatine supplementation among collegiate football players. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. J Neurol 2005;252(1):36-41. [The effect of creatine phosphate in patients after surgery in ischemic heart disease]. Rossouw F, Kruger PE, Rossouw J. Mazzini, L., Balzarini, C., Colombo, R., Mora, G., Pastore, I., De Ambrogio, R., and Caligari, M. Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Clin J Sport Med 1998;8:298-304. Gualano B, Macedo AR, Alves CR, et al. View abstract. The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. Int J Sport Nutr.Exerc.Metab 2000;10(3):277-289. Effects of creatine supplementation on body composition, strength, and sprint performance. Influence of creatine supplementation on the functional capacity of patients with heart failure. Muscle Nerve 2006;34(5):586-594. Persky AM, Muller M, Derendorf H, et al. View abstract. 1998;157(7):606-607. Int J Sport Nutr 1999;9:146-65. . The influence of recovery duration on high-intensity exercise performance after oral creatine supplementation. Taes, Y. E., Marescau, B., De, Vriese A., De Deyn, P. P., Schepers, E., Vanholder, R., and Delanghe, J. R. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Walter, M. C., Reilich, P., Lochmuller, H., Kohnen, R., Schlotter, B., Hautmann, H., Dunkl, E., Pongratz, D., and Muller-Felber, W. Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. View abstract. 2009;41(10):1934-1941. AAPS PharmSciTech 2003;4(2):E25. View abstract. View abstract. Bemben, M. G., Tuttle, T. D., Bemben, D. A., and Knehans, A. W. Effects of creatine supplementation on isometric force-time curve characteristics. 2004;51(4):875-882. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. The fix: ADP takes a phosphate molecule from your body’s stores of creatine phosphate, forming more ATP. Physiological response to exercise in the heat following creatine supplementation. View abstract. Vandebuerie, F., Vanden Eynde, B., Vandenberghe, K., and Hespel, P. Effect of creatine loading on endurance capacity and sprint power in cyclists. View abstract. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. ” says Purser. Stricker PR. Muscle cramps. 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